Cymbalta dosage. The recommended dose for treating depression is 20 or 30 mg twice daily or 60 mg once daily. Patients may be started with 30 mg once daily for one week before the dose is advanced to 60 mg daily. Effexor vs Cymbalta: Which Is Better for Depression? When treating depression, both drugs are similarly affective. In a randomized, double-blind study which compared Cymbalta 60mg a day and Effexor XR 150mg a day both Cymbalta and Effexor XR demonstrated substantial antidepressant efficacy and received a HAMD 17 total score. The major difference between Effexor and Cymbalta is that the former is available as a low-cost generic while the latter is still enjoying patent protection and associated pricing power. You will always find a few people who seem to really do much better on one drug compared to the other. I also know countless people that have failed to respond to Cymbalta, but did fine on Effexor. In a bare Knuckle brawl, I would give 10 to 1 odds in favor of Effexor VS Cymbalta. Find patient medical information for Cymbalta Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. I am thinking of switching my meds for depression I started on Paxil which made me blow up like a balloon in turn making me more depressed, Cymbalta, I slept about 14 hours a day and finally Zoloft. Duloxetine (Cymbalta) has a higher affinity for this type of receptor than venlafaxine (Effexor), which accounts for the somewhat higher rate of dry mouth, constipation, and blurred vision with duloxetine than with venlafaxine. Compare Celexa vs Effexor head-to-head for uses, ratings, cost, side effects, interactions and more. Celexa rated 7.4/10 vs Effexor rated 6.1/10 in overall patient satisfaction. Celexa rated 7.4/10 vs Effexor rated 6.1/10 in overall patient satisfaction. Compare Cymbalta vs. Venlafaxine, which is better for uses like: Depression, Anxiety and Fibromyalgia. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Cymbalta 3.4/5 over Venlafaxine 3.3/5 in overall satisfaction. I am hoping to go on an antidepressant after delivery in 8 weeks as I am suffering from bad depression and anxiety. I have been on an antidepressant before have tried (zoloft, paxil, wellbutrin and Effexor) and Effexor was what worked best for depression/anxiety/OCD and ADD.